He will host the show, which he has fronted since 1998, for the final time this afternoon.
Despite speculation that the veteran broadcaster would be well-placed to enter the race to succeed President Michael D Higgins later this year, Duffy said he has not been asked to run.
Speaking to RT脡鈥檚 Morning Ireland, the Liveline host said: “Ah no, I could see the 脕ras from Claddagh Green [in Ballyfermot], I鈥檇 say that鈥檚 the closest I鈥檒l ever get to it.鈥.
Asked whether he has been approached about mounting a presidential bid, he said: 鈥淎h no, I haven鈥檛. No, I haven鈥檛.
“And even if鈥 I鈥檓 still a part of RT脡 until Monday, effectively and if I say鈥f I had… Anyway, no, I will not lose the run of myself. I will not lose the run of myself.
“There鈥檚 some great, great names that have been mentioned so far.鈥
The broadcaster reflected on some of the major issues covered on the show while he was at the helm, including how it contributed to the closure of head shops in 2010.
“The head shop campaign was the only time 鈥 out of all the things we鈥檝e done over the years thanks to the listeners 鈥 that I was physically threatened,鈥 he said.
Duffy added that he was threatened twice, once in an underground car park and another on the street when he was 鈥渟pat at鈥.
He said it was an issue he was 鈥渧ery passionate about鈥 and while he couldn鈥檛 go to the protests, he “painted every single placard” for the Clontarf protest.
“It’s the voices on Liveline. The less I talk the better, I find. The less I talk the better. It’s the voices of the callers and it’s a privilege.鈥
He said his career in RT脡 started 鈥渁lmost accidentally鈥 as he was working as a probation officer with hopes of becoming a producer when he became a reporter for Gay Byrne鈥檚 programme.
Duffy admitted that he received a number of letters in the early days of being on air for his Ballyfermot accent, but that Byrne was 鈥渟uch a supporter鈥.
“He was very private. And we bounced off each other. He used to give out to me when he retired, he used to text me on Liveline, giving out to me.鈥
He added that Byrne was 鈥渟o intense鈥 on the idea that it was the public that 鈥減ay our wages鈥.
“鈥橮eople trust us, keep it that way. Stop on the street if people want to chat to you, what鈥檚 the big deal? Just stop, enjoy.鈥 And I do, I do like meeting people and I do like being on the Luas and talking to people, and being on the 130 and talking to people.鈥
Duffy said he made a habit of sending cards to those who called into the show to thank them, describing it as 鈥渁 joy鈥.
During yesterday’s show, listeners were calling Joe Duffy to say goodbye to him and wish him a good retirement, while Duffy teased today’s programme and described it as “special”.
“I’m told I know nothing about it. I will be here, and I hope you will join us,” he said.
Speaking during the show in May, when he announced he would retire at the end of June, he said: “After 37 wonderful years here in RT脡, and 27 years presenting Liveline, it has been an incredible honour and privilege to be part of a programme that relied entirely on trust: the trust of our listeners.
“People felt they could pick up the phone, ring Liveline, and share their lives, problems, stories, sad, bad, sometimes mad and funny, their struggles, and their victories.
“I never took that for granted, not for a single minute. RT脡 has been a great place to work. Public service has always been at its heart. And now, after many happy years, I鈥檝e decided the time has come to move on.
“I would like to thank you the listener for tuning in each and every day, it has been an honour to sit in this seat and hear your stories,” he added.
Born in January 1956, in Mountjoy Square, Dublin, and raised in Ballyfermot, Duffy originally pursued social work at Trinity College Dublin (TCD).
He became one of the first from his area to go to TCD and was actively involved in student politics and went on to serve as President of the Union of Students in Ireland.
He led protests on campus, highlighting access to education and spent two weeks in Mountjoy Prison as a result.
After working in the probation service, he joined RT脡 originally as a radio producer in 1989, and came to prominence as a reporter on the legendary Gay Byrne Show.
He presented programmes like Soundbyte before taking over Liveline in 1998.
In his 27 years in the Liveline hot seat, both Duffy and the programme itself have become national institutions, with the programme frequently attracting some 400,000 listeners.
RT脡 Radio One’s flagship phone-in show will now welcome a new host, with Katie Hannon tipped to take over from Duffy, for whom she regularly filled in for in recent years.
The speculations increased after it was announced on Tuesday that the Upfront with Katie Hannon will not return in September, possibly paving the way for her to take over the Liveline gig.
It is understood that a stand-in presenter will host the show on Monday, with the permanent successor being announced over the summer.