The 1975 and Olivia Rodrigo will join Neil Young as headliners at the festival.
CMAT will be the first of the Irish Acts to take to the stage on Friday on the Pyramid Stage at 1.30pm, followed by Inhaler on the Other Stage at 2.15pm.
While The Script will perform on the Pyramid Stage at 3pm and Kneecap will perform on Saturday on the West Holts Stage at 4pm.
Controversy has surrounded rap trio Kneecap and UK prime minister Keir Starmer has said he does not think Kneecap鈥檚 planned Glastonbury Festival performance is 鈥渁ppropriate鈥.
He made the comments after Kneecap member Liam Og O hAnnaidh appeared in court on Wednesday, after being charged for allegedly displaying a flag in support of proscribed terrorist organisation Hezbollah while saying 鈥渦p Hamas, up Hezbollah鈥 at a gig in November last year.
However, Glastonbury co-organiser Emily Eavis has said Kneecap is 鈥渨elcome鈥 at the festival despite Mr Starmer鈥檚 comments.
“There have been a lot of really heated topics this year, but we remain a platform for many, many artists from all over the world and, you know, everyone is welcome here,鈥 she said.
Meanwhile, Snow Patrol will take to the Other Stage on Sunday at 6pm.
Manchester-formed rockers The 1975 will perform on the Friday, Canadian legend Young heads up the Saturday, and US star Rodrigo will take the Sunday slot.
Multi-Brit winner and creator of the social phenomenon 鈥渂rat summer鈥 Charli XCX will play the Other Stage on Saturday night.
Hip-hop star Loyle Carner will also be on the same stage on Friday.
The Prodigy close the festival there on Sunday with a show that will be their first at the festival since the death of frontman Keith Flint in 2019.
Other acts announced include Biffy Clyro, Alanis Morissette, Noah Kahan, Wolf Alice, Wet Leg and the recently reformed Scissor Sisters. They join Snow Patrol, who will play on Sunday night.
Young was confirmed in January, after initially refusing to play the Pyramid Stage because of an 鈥渆rror in the information received鈥.
He had said the festival was under the 鈥渃orporate control鈥 of the BBC, because of the corporation鈥檚 broadcasting rights.
Rod Stewart was already confirmed for the teatime legends slot on the Sunday.
On the West Holts stage, American rapper and songwriter Doechii, who rose to prominence on TikTok, will perform for the first time.
Other first-timers include Gracie Abrams, Busta Rhymes, Lola Young and Brandi Carlile, who was nominated for a 2025 original song Oscar alongside Elton John.
Rising star Myles Smith, funk group Cymande, US rapper -Shaboozey and former Tubeway Army frontman Gary Numan will also make their Glastonbury debut.
The 1975 and Olivia Rodrigo announced as Glastonbury 2025 headliners
The 1975, fronted by Matty Healy, have headlined various festivals in the UK and around the world, with controversial stage antics.
Last month, the band was found not liable after a Malaysian festival was closed because Healy kissed a male bandmate on stage. They had been sued by the organisers of the Good Vibes Festival, Future Sound Asia, after they were forced to shut the event early by authorities in Malaysia, where homosexuality is a crime.
Rodrigo, meanwhile, is set to play her biggest Irish show to date when she takes to the stage at Marlay Park, Dublin, on June 24.
Other acts to play at Glastonbury in June include Franz Ferdinand, Blossoms, PinkPantheress, Self Esteem, and Raye.